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KMID : 1098420080160030183
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 3 p.183 ~ p.187
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Curcumin Attenuates Chronic Constriction Nerve Injury-Induced Neuropathic Pain in Rats
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Kim Chae-Eun
Park Eun-Sung
Jeon Young-Hoon
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Abstract
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Nerve injury can lead to neuropathic pain, which is often resistant to current analgesics and interventional therapeutic methods. Extracellular signal-regulated kinase (ERK) plays important role in the induction of neuropathic pain. We explored the antinociceptive effect of curcumin and its effect on ERK in the spinal cord in the neuropathic pain model of rats induced by chronic constriction injury (CCI) of the sciatic nerve. In injured rats, mechanical allodynia, which is one of characteristics of neuropathic pain developed and the activation of ERK in spinal cord significantly increased compared with control group. However, administration of curcumin (50 mg/kg/day p.o) for 7 days started from one day before the injury prevented the development of mechanical allodynia and increase of ERK phosphorylation. These results indicate that curcumin can be a new therapeutic agent in the treatment of neuropathic pain.
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KEYWORD
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Allodynia, Curcumin, ERK, Nerve injury, Neuropathic pain
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